coli (DAEC) pathotype, which comprises strains that adhere to epithelial cells in a diffused distribution. 5ДЄnother less well-defined pathotype has been described, that is, the diffusely-adherent E. coli isolates as a pathotype, because some isolates combine the main virulence characteristics of different pathotypes and are thus considered potentially more virulent hybrid pathogenic strains. coli genome has hindered the identification of certain E. Nevertheless, it should be pointed out that the plasticity of the E. coli (EIEC).Д®ach of these pathotypes represents a group of clones that share specific virulence factors. coli (EPEC), enterohemorrhagic (Shiga toxin-producing) E. 6 The DEC pathotypes differ regarding their preferential host colonization sites, virulence mechanisms, and the ensuing clinical symptoms and consequences, and are classified as enteropathogenic E. coli pathotypes, which are collectively known as diarrheagenic E. 3,5,6 According to the group of virulence determinants acquired, specific combinations were formed determining the currently known E. coli strains involved in diarrheal diseases are one of the most important of the various etiological agents of diarrhea, where strains have evolved by the acquisition, through horizontal gene transfer, of a particular set of characteristics that have successfully persisted in the host. 4 Low- and middle-income countries in Africa, Asia and Latin America are the most affected regions with diarrheal diseases occurring more often with lethal outcomes mainly due to poor living conditions (inadequate water supplies, poor environmental hygiene and sanitation, and insufficient education). 3Дiarrheal illnesses are a severe public health problem and a major cause of morbidity and mortality in infants and young children. coli strains live harmlessly in the colon and seldom cause disease in healthy individuals, a number of pathogenic strains can cause intestinal and extraintestinal diseases both in healthy and immunocompromised individuals. 1 The genus type species Escherichia coli is widely distributed, where it is the major facultative anaerobe inhabiting the large intestine of humans and warm-blooded animals. The genus Escherichia, which was named after the German pediatrician Theodor Escherich, consists of facultative anaerobic Gram-negative bacilli that belong to the family Enterobacteriaceae.

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